Drug-Drug Interaction Checker API & Plugin

Prescribing just got safer

Improve patient outcomes, assist in clinical decision-making, and reduce medical errors.

Check 1.3+ million drug-drug interactions with a single API call

Search by ingredient identifiers, product identifiers (such as NDC codes), RxNorm codes, or product concept identifiers.

Each interaction includes

  • Severity rating
  • Detailed drug-drug interaction mechanism description
  • Interaction management description
Drug-Drug Interaction Checker
The metabolism of (R)-warfarin can be increased when combined with Acetaminophen.
Extended Description:
Warfarin is primarily metabolized by CYP2C9 and to a lesser extent by CYP2C19 and CYP3A4. Agents known to be strong CYP3A4 inducers will increase the metabolism of warfarin. Hence, concomitant use of these agents will reduce warfarin plasma concentrations and should be avoided if possible [FDA label].
Evidence Level:
Level 1
Avoid concurrent use of warfarin and CYP3A4 inducers whenever possible. If the combination must be used, conduct additional INR monitoring and adjust the dosage as necessary when starting, stopping, or changing the dosage of a CYP3A4 inducer.
API Query
  "interactions": [
      "ingredient": {
        "drugbank_id": "DB00316",
        "name": "Acetaminophen"
      "affected_ingredient": {
        "drugbank_id": "DB00682",
        "name": "Warfarin"
      "description": "The risk or severity of adverse effects can be increased when Acetaminophen is combined with Warfarin.",
      "extended_description": "Chronic oral acetaminophen use at a dose of 4,000 mg/day has been demonstrated to cause an increase in the international normalized ratio (INR) for some patients who have been stabilized on sodium warfarin as an anticoagulant. This interaction is thought to occur through augmented effects on vitamin K antagonism, increasing the risk of bleeding.",
      "action": "increase_adverse_effects",
      "severity": "moderate",
      "subject_dosage": null,
      "affected_dosage": null,
      "evidence_level": "level_1",
      "management": "Use this combination with caution. Avoid warfarin doses of 4, 000 mg/day or higher when acetaminophen is used, and regularly monitor INR. Adjust drug dosage as necessary, according to clinical response."
  "total_results": 1

Drug Input

Choose up to 40 different drugs and check for all interactions between them in a single request.


A brief description of the drug-drug interaction.

Extended Description

A detailed description of why the interaction occurs and the effect of the interaction.


The severity of each drug interaction is rated as minor, moderate or major.

Evidence Level

A rating for the strength of the evidence supporting each drug interaction.


The recommended procedure to deal with this type of drug-drug interaction.


Drug-Drug Interaction

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Drug-Drug Interaction Checker to your software.